調(diào)強(qiáng)放療中計(jì)算機(jī)應(yīng)用技術(shù)研究

第1 章 引言······················································································1
1.1 研究背景及意義······································································1
1.1.1 癌癥的嚴(yán)重危害·····························································1
1.1.2 癌癥的治療方法·····························································3
1.1.3 放療對(duì)于癌癥治療的貢獻(xiàn)················································4
1.1.4 放療技術(shù)發(fā)展的巨大潛力················································5
1.2 放療技術(shù)的發(fā)展歷史································································8
1.2.1 初級(jí)放療時(shí)代································································8
1.2.2 常規(guī)放療時(shí)代································································9
1.2.3 精準(zhǔn)放療時(shí)代································································9
1.2.4 小結(jié)·········································································.10
1.3 計(jì)算機(jī)應(yīng)用技術(shù)對(duì)調(diào)強(qiáng)放療技術(shù)的支撐作用·······························.11
第2 章 放療中的硬件及放療計(jì)劃系統(tǒng)·················································.13
2.1 放療的分類·········································································.13
2.1.1 基本概念···································································.13
2.1.2 放療設(shè)備···································································.17
2.1.3 照射方式···································································.28
2.1.4 放療目的···································································.32
2.1.5 放療手段和技術(shù)··························································.33
2.1.6 劑量分割方式·····························································.37
2.2 放療的生物學(xué)原理································································.38
2.3 調(diào)強(qiáng)放療的步驟···································································.40
2.4 調(diào)強(qiáng)放療中的射線調(diào)制設(shè)備····················································.43
2.5 逆向計(jì)劃系統(tǒng)······································································.45
第3 章 調(diào)強(qiáng)放療中的規(guī)劃問題···························································.48
3.1 正向調(diào)強(qiáng)規(guī)劃和逆向調(diào)強(qiáng)規(guī)劃·················································.48
3.1.1 正向調(diào)強(qiáng)規(guī)劃·····························································.48
3.1.2 逆向調(diào)強(qiáng)規(guī)劃·····························································.49
3.2 調(diào)強(qiáng)放療中的數(shù)學(xué)優(yōu)化問題····················································.49
3.3 劑量計(jì)算模型和相關(guān)描述·······················································.50
3.4 放療計(jì)劃系統(tǒng)中的可行性問題·················································.51
3.5 調(diào)強(qiáng)放療中的規(guī)劃模型··························································.51
3.5.1 線性和非線性規(guī)劃模型················································.51
3.5.2 放射生物學(xué)模型··························································.53
3.5.3 劑量體積約束模型·······················································.56
3.5.4 劑量體積約束優(yōu)化問題················································.60
3.5.5 規(guī)范化距離信息排序···················································.63
3.5.6 混合整數(shù)規(guī)劃模型·······················································.68
3.5.7 多目標(biāo)規(guī)劃模型··························································.69
3.5.8 照射角度選擇優(yōu)化模型················································.72
第4 章 通量圖的平滑方法·································································.75
4.1 通量圖的生成和調(diào)制·····························································.75
4.2 通量圖的平滑······································································.78
4.3 圖像去噪原理······································································.79
4.4 基于機(jī)器跳數(shù)的平滑方法·······················································.83
4.4.1 基于圖像處理的平滑方法存在的問題······························.83
4.4.2 基于多葉準(zhǔn)直器的靜態(tài)調(diào)強(qiáng)放療的劑量調(diào)制過程···············.84
4.4.3 無葉片碰撞約束的模型················································.87
4.4.4 后驅(qū)葉片同步約束模型················································.88
4.4.5 前驅(qū)葉片同步約束模型················································.90
4.4.6 前后葉片中心時(shí)長同步模型··········································.91
4.4.7 舌槽欠劑量效應(yīng)的直接約束··········································.94
4.4.8 帶葉片碰撞約束的模型················································.95
4.5 雙向葉片運(yùn)動(dòng)通量圖平滑模型·················································.96
4.5.1 雙向葉片運(yùn)動(dòng)通量圖平滑模型介紹·································.96
4.5.2 實(shí)驗(yàn)及結(jié)果分析······················································